Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis
Abstract Glioblastoma multiforme (GBM) is characterized by pronounced Molybdenum immune escape and resistance to chemotherapy-induced apoptosis.Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM.Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, co