ENGINEERED BIOMIMETIC CISPLATIN-POLYPHENOL NANOCOMPLEX FOR CHEMO-IMMUNOTHERAPY OF GLIOBLASTOMA BY INDUCING PYROPTOSIS

Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis

Abstract Glioblastoma multiforme (GBM) is characterized by pronounced Molybdenum immune escape and resistance to chemotherapy-induced apoptosis.Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM.Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, co

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